名称：Progesterone Receptor(Phospho-Ser190)

别名：NR3C3; PGR; PRGR

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

文献

Narayanan R, et al. (2005) Mol Cell Biol; 25(8): 2885-98.Knotts TA, et al. (2001) J Biol Chem; 276(11): 8475-83.Clemm DL, et al. (2000) Mol Endocrinol; 14(1): 52-65.Zhang Y, et al. (1997) Mol Endocrinol; 11(6): 823-32

Specification

Entrez GeneID：5241;

Swissprot：P06401

Gene Accession：Swiss-Prot: P06401NCBI Protein: NP_000917.3

WB Predicted band size：99kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A) derived from Human Progesterone Receptor.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit