名称：MEK2(Phospho-Thr394)

别名：ERK activator kinase 2; MAP kinase kinase 2; MAP2K2; MAPK/ERK kinase 2; MAPKK 2

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.

文献

Crews C M, et al. (1992) Science. 258:478-480.Alessi D R, et al. (1994) EMBO J. 13:1610-1619.Rosen L B, et al. (1994) Neuron. 12:1207-1221.Cowley S, et al. (1994) Cell. 77:841-852.

Specification

Entrez GeneID：5605;

Swissprot：P36507

Gene Accession：Swiss-Prot: P36507NCBI Protein: NP_109587.1

WB Predicted band size：44kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of threonine 394 (P-G-T(p)-P-T) derived from Human MEK-2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit