名称：EPHA2/3/4 (Phospho-Tyr588/596)

别名：ECK; MPK-5; SEK2; kinase EphA2;

Pathway：PI3K-Akt signaling pathway

Pathway：Hippo signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990)Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005)Zhuang G., J. Biol. Chem. 282:2683-2694(2007)

Specification

Entrez GeneID：1969;

Swissprot：P29317

Gene Accession：Swiss-Prot#: P29317/P29320/P54764; NCBI Gene#: 1969/2042/2043; NCBI Protein#: NP_004422.2.

WB Predicted band size：130kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/1000

ICC：1/100-1/200

宿主：Rabbit