名称：NMDAR1 (Phospho-Ser890)

别名：GLURZ1; GRIN1; NMD-R1; NMDZ1; NMZ1

Modified：Phosphorylated

Targets：Disease

描述

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

文献

Guang Bai, J. Biol. Chem., Jan 1998; 273: 1086. Guang Bai, J. Biol. Chem., Mar 1995; 270: 7737. Mai T. Dang, PNAS, Oct 2006; 103: 15254 - 15259

Specification

Entrez GeneID：2902;

Swissprot：Q05586

Gene Accession：Swiss-Prot#: Q05586; NCBI Gene#: 2902; NCBI Protein#: NP_015566.1.

WB Predicted band size：120kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC,IF

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit