名称：MLC2 (Phospho-Ser15)

别名：CMH10, MFM12, MLC-2, MLC-2s/v, MLC-2v, MLC2

Modified：Phosphorylated

Targets：Disease

描述

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.

文献

1) Xia, Y. et al. c-Jun downregulation by HDAC3-dependent transcriptionalrepression promotes osmotic stress-induced cell apoptosis. Mol. Cell 25,219–232 (2007).

2)Vander Heiden, M. G. et al. Evidence for an alternative glycolytic pathway inrapidly proliferating cells. Science 329, 1492–1499 (2010).

3) Fang, D. et al. Phosphorylation of beta-catenin by AKT promotes beta-catenintranscriptional activity. J. Biol. Chem. 282, 11221–11229 (2007).

Specification

Entrez GeneID：4633;

Swissprot：P10916

Gene Accession：Swiss-Prot#: P10916NCBI Gene ID: 4633NCBI Protein#: NP_006088.2

WB Predicted band size：20kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 15 (A-N-S(p)-N-V) derived from Human MLC2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/1000

ICC：1/100-1/200

宿主：Rabbit