名称：E2A (Phospho-Thr355)

别名：E12; Tran; TCF3; TFE2; ITF1

Modified：Phosphorylated

Targets：Disease

描述

E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. Kamps M.P., Cell 60:547-555(1990)Nourse J., Cell 60:535-545(1990)Grimwood J., Nature 428:529-535(2004)

Specification

Entrez GeneID：6929;

Swissprot：P15923

Gene Accession：Swiss-Prot#: P15923; NCBI Gene#: 6929; NCBI Protein#: NP_003191.1.

WB Predicted band size：67kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of threonine 355 (P-S-T(p)-P-V) derived from Human E2A .

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit