名称：IKK- gamma (Phospho-Ser31)

别名：FIP-3; FIP3; I-kappa-B kinase gamma; IKBKG; IKKAP1

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Carter RS, Pennington KN, Ungurait BJ, Ballard DW (2003)J Biol Chem 278, 19642-8.

Specification

Entrez GeneID：8517;

Swissprot：Q9Y6K9

Gene Accession：Swiss-Prot#: Q9Y6K9; NCBI Gene#: 8517; NCBI Protein#: NP_001093326.2

WB Predicted band size：48kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of serine 31 (E-E-S(p)-P-L) derived from Human IKK-gamma.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit