名称：ASK1(Phospho-Ser83)

别名：ASK-1; M3K5; MAP3K5; MAPK/ERK kinase kinase 5; MAPKKK5

Pathway：MAPK signaling pathway

Modified：Phosphorylated

描述

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

文献

Mabuchi S, et al. (2004) Endocrinology. 145(1): 49-58.

Yuan ZQ, et al. (2003) J Biol Chem. 278(26): 23432-23440.

Kim AH, et al. (2001) Mol Cell Biol. 21(3): 893-901.

Specification

Entrez GeneID：4217;

Swissprot：Q99683

Gene Accession：Swiss-Prot: Q99683NCBI Protein: NP_005914.1

WB Predicted band size：155kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 83 (G-S-S(p)-V-G) derived from Human ASK1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit