名称：p53(Phospho-Ser315)

别名：Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

文献

Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-5934.Lohrum, M. et.al. (1996) Oncogene 13, 2527-2539.Posp

Specification

Entrez GeneID：7157;

Swissprot：P04637

Gene Accession：Swiss-Prot: P04637NCBI Protein: NP_000537.3

WB Predicted band size：53kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 315 (S-S-S(p)-P-Q) derived from Human p53.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit