名称：COCH

别名：Cochlin, COCH-5B2, COCH, COCH5B2

Targets：Disease

描述

The protein encoded by this gene is highly conserved in

human, mouse, and chicken, showing 94% and 79% amino acid identity

of human to mouse and chicken sequences, respectively.

Hybridization to this gene was detected in spindle-shaped cells

located along nerve fibers between the auditory ganglion and

sensory epithelium. These cells accompany neurites at the habenula

perforata, the opening through which neurites extend to innervate

hair cells. This and the pattern of expression of this gene in

chicken inner ear paralleled the histologic findings of acidophilic

deposits, consistent with mucopolysaccharide ground substance, in

temporal bones from DFNA9 (autosomal dominant nonsyndromic

sensorineural deafness 9) patients. Mutations that cause DFNA9 have

been reported in this gene. Alternative splicing results in

multiple transcript variants encoding the same protein. Additional

splice variants encoding distinct isoforms have been described but

their biological validities have not been demonstrated. [provided

by RefSeq].

Specification

Entrez GeneID：1690

Swissprot：O43405

WB Predicted band size：59.5kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/1000

宿主：Rabbit