名称：IKK- alpha/ beta (Phospho-Ser180/181)

别名：FLJ40509; I-kappa-B kinase; IKBKB; kinase beta; NFKBIKB

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Modified：Phosphorylated

描述

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.Hafeez BB, et al. (2008) Cancer Res 68, 8564-72 Cahill CM, Rogers JT (2008) J Biol Chem 283, 25900-12 Encinas M, et al. (2008)Cell Death Differ 15, 1510-21

Specification

Entrez GeneID：1147;

Swissprot：O15111

Gene Accession：Swiss-Prot#: O15111/O14920; NCBI Gene#: 1147; NCBI Protein#: NP_001269.3

WB Predicted band size：85kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of serine 180/181 (C-T-S(p)-F-V) derived from Human IKK- alpha/ beta.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit