名称：Gab2 (Phospho-Tyr643)

别名：pp100; GABJ; KIAA0571;

Modified：Phosphorylated

描述

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene

文献

Nishida K., Blood 93:1809-1816(1999)

Nagase T., DNA Res. 5:31-39(1998)

Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).

Specification

Entrez GeneID：9846;

Swissprot：Q9UQC2

Gene Accession：Swiss-Prot#: Q9UQC2; NCBI Gene#: 9846; NCBI Protein#: NP_536739.1.

WB Predicted band size：74kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 643(V-D-Y(p)-V-Q) derived from Human Gab2 .

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit