名称：TrkA(Phospho-Tyr791)

别名：High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Pathway：Hippo signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

文献

Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5.

Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5

Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84

Specification

Entrez GeneID：4914;

Swissprot：P04629

Gene Accession：Swiss-Prot: P04629NCBI Protein: NP_001007793.1

WB Predicted band size：140kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/1000

ICC：1/100-1/200

宿主：Rabbit