名称：BRCA2 (Phospho-Ser3291)

别名：BRCC2; BRCA2; subunit 2; BRCA1/BRCA2-containing complex;

Modified：Phosphorylated

Targets：Disease

描述

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. Wooster R., Nature 378:789-792(1995)Tavtigian S.V., Nat. Genet. 12:333-337(1996)Dunham A., Nature 428:522-528(2004)

Specification

Entrez GeneID：675;

Swissprot：P51587

Gene Accession：Swiss-Prot#: P51587; NCBI Gene#: 675; NCBI Protein#: NP_000050.2.

WB Predicted band size：>350kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit