名称：AKT1/3 (Phospho-Tyr437/434)

别名：EC 2.7.11.1; RAC-PK-alpha; Protein kinase B; PKB; C-AKT

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：mTOR signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.

Specification

Entrez GeneID：207;

Swissprot：P31749

Gene Accession：Swiss-Prot#:P31749/Q9Y243;NCBI Gene#:207/208/10000

WB Predicted band size：56kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 437 (T-R-Y(p)-F-D) derived from Human AKT1/3.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/3000

IHC：1/50-1/100

宿主：Rabbit