名称：CCNT1

别名：Cyclin-T1, CycT1, Cyclin-T, CCNT1

描述

CCNT1 belongs to the highly

conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle.

Cyclins function as regulators of CDK kinases. Different cyclins

exhibit distinct expression and degradation patterns which

contribute to the temporal coordination of each mitotic event. This

cyclin tightly associates with CDK9 kinase, and was found to be a

major subunit of the transcription elongation factor p-TEFb. The

kinase complex containing this cyclin and the elongation factor can

interact with, and act as a cofactor of human immunodeficiency

virus type 1 (HIV-1) Tat protein, and was shown to be both

necessary and sufficient for full activation of viral

transcription. This cyclin and its kinase partner were also found

to be involved in the phosphorylation and regulation of the

carboxy-terminal domain (CTD) of the largest RNA polymerase II

subunit.

Specification

Entrez GeneID：904

Swissprot：O60563

WB Predicted band size：80.7kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human, Mouse

免疫原：This CCNT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the Central region of human CCNT1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/1000

宿主：Rabbit