名称：ESPL1(Phospho-S1126/801)

别名：ESP1; SEPA

Modified：Phosphorylated

描述

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Specification

Entrez GeneID：9700;

Swissprot：Q14674

Gene Accession：Swiss-Prot#: Q14674NCBI Gene ID: 9700

WB Predicted band size：233kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：A phospho specific peptide corresponding to residues surrounding S1126 of human ESPL1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/2000

ICC：1/20-1/100

宿主：Rabbit