名称：ABL1 (Phospho-Thr735)

别名：Abelson murine leukemia viral oncogene 1; ABL1; c-ABL; JTK7; p150

Pathway：Jak-STAT signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. Fainstein E., Oncogene 4:1477-1481(1989)Shtivelman E., Cell 47:277-284(1986)Chissoe S.L., Genomics 27:67-82(1995).

Specification

Entrez GeneID：25;

Swissprot：P00519

Gene Accession：Swiss-Prot#: P00519; NCBI Gene#: 25; NCBI Protein#: NP_005148.2.

WB Predicted band size：135kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of threonine735 (S-V-T(p)-L-P) derived from Human ABL1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit