名称：Tau(Phospho-Ser404)

别名：MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau

Pathway：MAPK signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

文献

Li G, Yin H, et.al .(2004) J Biol Chem ; 279(16): 15938-45.

Noble W, et al. (2003) Neuron ; 38(4): 555-65.

Giasson BI, et al.(2002). Biochemistry; 41(51): 15376-87.

Lee G., et.al. (1989). Neuron 2:1615-1624.

Andreadis A.et.al. (1992) Biochemistry 31:10626-10633.

Specification

Entrez GeneID：4137;

Swissprot：P10636

Gene Accession：Swiss-Prot: P10636NCBI Protein: NP_001116538.1

WB Predicted band size：48 62 78 kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of serine 404 (D-T-S(p)-P-R) derived from Human Tau.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit