名称：IGF2R (Phospho-Ser2409)

别名：CI-MPR; CI-MPR; MPR300; MPRI;

Modified：Phosphorylated

描述

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.Morgan D.O., Nature 329:301-307(1987)Oshima A., J. Biol. Chem. 263:2553-2562(1988)Killian J.K., Mamm. Genome 10:74-77(1999)

Specification

Entrez GeneID：3482;

Swissprot：P11717

Gene Accession：Swiss-Prot#: P11717; NCBI Gene#: 3482; NCBI Protein#: NP_000867.2.

WB Predicted band size：300kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit