名称：TPSAB1

别名：Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1

描述

Tryptases comprise a family of trypsin-like serine

proteases, the peptidase family S1. Tryptases are enzymatically

active only as heparin-stabilized tetramers, and they are resistant

to all known endogenous proteinase inhibitors. Several tryptase

genes are clustered on chromosome 16p13.3. These genes are

characterized by several distinct features. They have a highly

conserved 3' UTR and contain tandem repeat sequences at the 5'

flank and 3' UTR which are thought to play a role in regulation of

the mRNA stability. These genes have an intron immediately upstream

of the initiator Met codon, which separates the site of

transcription initiation from protein coding sequence. This feature

is characteristic of tryptases but is unusual in other genes. The

alleles of this gene exhibit an unusual amount of sequence

variation, such that the alleles were once thought to represent two

separate genes, alpha and beta 1. Beta tryptases appear to be the

main isoenzymes expressed in mast cells; whereas in basophils,

alpha tryptases predominate. Tryptases have been implicated as

mediators in the pathogenesis of asthma and other allergic and

inflammatory disorders.

Specification

Entrez GeneID：7177

Swissprot：Q15661

WB Predicted band size：30.5kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the Central region of human TPSAB1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,FCM

WB：1/1000

FCM：1/10-1/50

宿主：Rabbit