名称：Phospho-Nephrin(Y1193))

别名：Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN

Modified：Phosphorylated

Targets：Disease

描述

This gene encodes a member of the immunoglobulin family of

cell adhesion molecules that functions in the glomerular filtration

barrier in the kidney. The gene is primarily expressed in renal

tissues, and the protein is a type-1 transmembrane protein found at

the slit diaphragm of glomerular podocytes. The slit diaphragm is

thought to function as an ultrafilter to exclude albumin and other

plasma macromolecules in the formation of urine. Mutations in this

gene result in Finnish-type congenital nephrosis 1, characterized

by severe proteinuria and loss of the slit diaphragm and foot

processes.

Specification

Entrez GeneID：4868

Swissprot：O60500

WB Predicted band size：134.7kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：This Nephrin Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1193 of human Nephrin.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：DB: 1/500

宿主：Rabbit