名称：Presenilin 1

别名：PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182

Pathway：Notch signaling pathway

Targets：Disease

描述

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity.

Specification

Entrez GeneID：5663

Swissprot：P49768

WB Predicted band size：Calculated MW: 53 kDa; Observed MW: 20 kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：A synthetic peptide of human Presenilin 1

Formulation：Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application

Application：WB,IP,IF

WB：1/500-1/1000

IP：1/10-1/20

ICC：1/50-1/200

宿主：Rabbit