名称：PI3 Kinase p85 alpha

别名：PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：Jak-STAT signaling pathway

Targets：Disease

描述

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Specification

Entrez GeneID：5295

Swissprot：P27986

WB Predicted band size：Calculated MW: 84 kDa; Observed MW: 84 kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Rat,Hamster

免疫原：A synthetic peptide of human PI 3 Kinase p85 alpha

Formulation：Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application

Application：WB,IP,IF

WB：1/500-1/1000

IP：1/10-1/20

ICC：1/50-1/200

宿主：Rabbit