ProMab P22171 Rabbit Monoclonal Antibody to VPS41
- 销售价:
- ¥1280.00
- 市场价:
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¥1280.00 - 编号:
- 202602121098679
- 货号:
- P22171-50ul
-
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商品介绍
名称:VPS41
别名:HVPS41; HVSP41; hVps41p
Targets:Disease
描述Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex . May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).
Specification
Entrez GeneID:27072
Swissprot:P49754
WB Predicted band size:Calculated MW: 99 kDa; Observed MW: 99 kDa
Host/Isotype:Rabbit IgG
Antibody Type:Primary antibody
Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity:Human,Mouse,Rat
免疫原:A synthetic peptide of human VPS41
Formulation:Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.
Application
Application:WB
WB:1/500-1/1000
宿主:Rabbit
商品参数
| 商品介绍 | |
|---|---|
| 单位 | 支 |
| 品牌 | ProMab/远泰 |
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