名称：TCF7L2

别名：TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4;;TCF7L2

描述

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1.

Specification

Swissprot：Q9NQB0

WB Predicted band size：68 kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：A synthesized peptide derived from human TCF7L2

Formulation：Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

Application

Application：WB,IHC/IHF,IF,IP,FCM

WB：1/1000-1/5000

IP：1/20-1/50

IHC：IHC:1/100-1/200;IHF:1/50-1/200

ICC：1/50-1/200

FCM：1/20-1/100

宿主：Rabbit