名称：Caspase-3

别名：CASP3;CPP32;Caspase-3;CASP-3;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1

Targets：Caspase-3

描述

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],

Specification

Entrez GeneID：836

Swissprot：P42574

WB Predicted band size：31.6kD

Host/Isotype：Rabbit IgG,Kappa

Antibody Type：Primary antibody

Storage：-15°C to -25°C/1 year(Do not lower than -25°C)

Species Reactivity：Human,Mouse,Rat,

Formulation：PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Application

Application：WB,IHC,IF,IP,ELISA

WB：1/1000-5000

IP：1/50-200

IHC：1/200-1000

ICC：1/200-1000

ELISA：1/5000-20000

宿主：Rabbit