名称：MCM3

别名：HCC5; P1.h; RLFB; P1-MCM3

描述

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.

文献

1.Comput Math Methods Med. 2021 Oct 11;2021:8494260.
2.Biosci Rep. 2020 Jul 31;40(7):BSR20201503.

Specification

Entrez GeneID：4172

Swissprot：P25205

clone：1D4A3

WB Predicted band size：91kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Rat,Monkey

免疫原：Purified recombinant fragment of human MCM3 expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,IHC,IF,FCM

WB：1/500 - 1/2000

IHC：1/200 - 1/1000

ICC：1/50 - 1/200

FCM：1/200 - 1/400

宿主：Mouse