名称：CD269

别名：BCMA; TNFRSF17; BCM; TNFRSF13A

Pathway：TGF-beta signaling pathway

描述

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

文献

1.Lupus. 2016 May;25(6):582-92.
2.Crit Rev Immunol. 2012;32(4):287-305.

Specification

Entrez GeneID：608

Swissprot：Q02223

clone：1D12G9

WB Predicted band size：20.2kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of human BCMA (AA: QMAGQCSQNEYFDSLc) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：FCM

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse