名称：TUBB3

别名：CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4

Targets：Disease

描述

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

Specification

Entrez GeneID：10381

Swissprot：Q13509

clone：8E3A7

WB Predicted band size：50kDa

Host/Isotype：Mouse IgG1

Antibody Type：Loading Control Antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human, Mouse

免疫原：436-450:cMYEDDEEESEAQGPK

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,IHC,FCM

WB：1/500 - 1/2000

IHC：1/200 - 1/1000

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse