名称：PD1

别名：PDCD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1

Targets：FDA approved drug target related

描述

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

文献

1.Am J Surg Pathol. 2018 Jul;42(7):843-854.
2.PLoS One. 2018 Feb 28;13(2):e0192704.

Specification

Entrez GeneID：5133

Swissprot：Q15116

clone：3B3D9

WB Predicted band size：31.6kDa

Host/Isotype：Mouse IgG2b

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of human PD1 (AA: 192-288) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,FCM

WB：1/500 - 1/2000

FCM：1/200-1/400

ELISA：1/10000

宿主：Mouse