名称：MIB1

别名：MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2

Pathway：Notch signaling pathway

Targets：Disease

描述

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).

文献

1.J Cell Sci. 2015 May 1;128(9):1674-82.
2.Cell Res. 2012 Mar;22(3):603-6.

Specification

Entrez GeneID：57534

Swissprot：Q86YT6

clone：2A7B1

WB Predicted band size：110kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Monkey

免疫原：Purified recombinant fragment of human MIB1 (AA: 6-221) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,FCM

WB：1/500 - 1/2000

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse