名称：ESR1

别名：ER; ESR; Era; ESRA; ESTRR; NR3A1

Targets：Disease

描述

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

文献

1.Tumour Biol. 2015 Aug;36(8):6349-59.
2.Breast Cancer Res. 2014 Dec 12;16(6):494.

Specification

Entrez GeneID：2099

Swissprot：P03372

clone：6A6E8

WB Predicted band size：66.2kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat,Rabbit

免疫原：Purified recombinant fragment of human ESR1 (AA: 2-185) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,IHC,IF,FCM

WB：1/500 - 1/2000

IHC：1/100 - 1/500

ICC：1/50 - 1/500

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse