名称：ABL2

别名：ARG; ABLL; FLJ22224; FLJ31718; FLJ41441

描述

ABL2(ARG, Abelson-related gene) is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. c-Abl shows both cytoplasmic and nuclear localization,c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl.

文献

1. Yoshimi I, Takashi I, Tsuneyuki O, et al. Blood. 2000; 95(6): 2126-2131.
2. Scheijen, B. and Griffin, J.D. Oncogene. 2002); 21:3314-33.

Specification

Entrez GeneID：27

Swissprot：P42684

clone：1H1B11

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of ABL2 expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IF

ICC：1/200 - 1/1000

ELISA：1/10000

宿主：Mouse