名称：PKD1

别名：PC1; Mflj00285

描述

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.

文献

FASEB J. 2011 Jul;25(7):2418-32.
PLoS One. 2012;7(9):e46038.

Specification

Entrez GeneID：18763

Swissprot：O08852

clone：8C3D11

WB Predicted band size：466kDa

Host/Isotype：Rat IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：FCM

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Rat