名称：HAS1

别名：HAS; HAS1

描述

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

文献

1. Clin Lymphoma. 2005 Mar;5(4):253-6.
2. Mol Cell Biochem. 2006 Nov;292(1-2):169-78.
3. J Biol Chem. 2008 Jun 13;283(24):16781-9.

Specification

Entrez GeneID：3036

Swissprot：Q92839

clone：3E10

WB Predicted band size：65kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of human HAS1 expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IF

ICC：1/200 - 1/1000

ELISA：1/10000

宿主：Mouse