名称：ITGAM

别名：CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

描述

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

文献

1. Ann Rheum Dis. 2012 Dec;71(12):2028-34.
2. J Infect Chemother. 2011 Apr;17(2):291-6.

Specification

Entrez GeneID：3684

Swissprot：P11215

clone：3A10H5

WB Predicted band size：127.1kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：IF

ICC：1/200 - 1/1000

ELISA：1/10000

宿主：Mouse