名称：JAK3

别名：JAKL; LJAK

Pathway：PI3K-Akt signaling pathway

Pathway：Jak-STAT signaling pathway

Targets：Disease

描述

JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

文献

1. J Biol Chem. 1995 Oct 20;270(42):25028-36.
2. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6374-8.
3. Leuk Lymphoma. 2002 Dec;43(12):2355-62.

Specification

Entrez GeneID：3718

Swissprot：P52333

clone：5H2

WB Predicted band size：125kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Purified recombinant fragment of human JAK3 expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF,FCM

WB：1/500 - 1/2000

ICC：1/200 - 1/1000

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse