名称：MAP2K6

别名：MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6

Pathway：TGF-beta signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

描述

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas .

文献

1. J Mol Med. 2008 Apr;86(4):485-90.
2. Blood. 2007 Jan 1;109(1):185-93.

Specification

Entrez GeneID：5608

Swissprot：P52564

clone：3H12C8

WB Predicted band size：38kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Purified recombinant fragment of human MAP2K6 expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,IF,FCM

WB：1/500 - 1/2000

ICC：1/200 - 1/1000

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse