名称：PPM1A

别名：PP2CA; PP2Calpha; PP2C-ALPHA

描述

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

文献

1.Biol Psychiatry. 2011 Feb 15;69(4):360-5.
2.Cell Signal. 2009 Jan;21(1):95-102.

Specification

Entrez GeneID：5494

Swissprot：P20265

clone：7F12H6

WB Predicted band size：42.4kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Monkey

免疫原：Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：WB,FCM

WB：1/500 - 1/2000

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse