名称：SEMAPHORIN-3A

别名：SEMA3A;HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III

Pathway：TGF-beta signaling pathway

Targets：Disease

描述

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

文献

1. Arthritis Res Ther. 2012 Jun 14;14(3):R146.
2. Birth Defects Res A Clin Mol Teratol. 2011 Sep;91(9):842-7.

Specification

Entrez GeneID：10371

Swissprot：Q14563

clone：1G6F9

WB Predicted band size：89kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Synthesized peptide of human SEMAPHORIN-3A (AA: 359-372).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：FCM

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse