名称：KIT

别名：PBT; SCFR; C-Kit; CD117

Pathway：PI3K-Akt signaling pathway

Pathway：Hippo signaling pathway

Targets：Disease

描述

The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.

文献

1. Curr Hematol Malig Rep. 2009 Apr;4(2):77-82.
2. Georgian Med News. 2010 Mar;(180):13-9.

Specification

Entrez GeneID：3815

Swissprot：P10721

clone：1C5

WB Predicted band size：145kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of human KIT expressed in E. Coli.

Formulation：Ascitic fluid containing 0.03% sodium azide.

Application

Application：WB,IHC

WB：1/500 - 1/2000

IHC：1/200 - 1/1000

ELISA：1/10000

宿主：Mouse