名称：AKT2

别名：PKBB; PRKBB; PKBBETA; RAC-BETA

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Targets：Disease

描述

Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

文献

1. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E8-E15.
2. Oncol Rep. 2004 Jan;11(1):25-32.
3. Cancer Res. 2003 Jan 1;63(1):196-206.

Specification

Entrez GeneID：208

Swissprot：P31751

clone：1B6

WB Predicted band size：60kDa

Host/Isotype：Mouse IgG2b

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Rat,Monkey

免疫原：Purified recombinant fragment of human AKT2 expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500 - 1/2000

IHC：1/200 - 1/1000

ICC：1/200 - 1/1000

ELISA：1/10000

宿主：Mouse