名称：IL3RA

别名：IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：Jak-STAT signaling pathway

Targets：FDA approved drug target related

描述

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.

文献

1. Am J Clin Pathol. 2011 Oct;136(4):625-30.
2. Chin Med J (Engl). 2010 Aug 5;123(15):2034-7.

Specification

Entrez GeneID：3563

Swissprot：P26951

clone：8E11C5

WB Predicted band size：43.3kDa

Host/Isotype：Mouse IgG1

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Purified recombinant fragment of human IL3RA (AA: 200-305) expressed in E. Coli.

Formulation：Purified antibody in PBS with 0.05% sodium azide

Application

Application：IHC,IF,FCM

IHC：1/200 - 1/1000

ICC：1/200 - 1/1000

FCM：1/200 - 1/400

ELISA：1/10000

宿主：Mouse