产品编号：bs-0291P

英文名称：Bovine Thyroglobulin

中文名称：甲状腺球蛋白（牛）（进口）

英文别名：Thyroglobulin from bovine thyroid; TG;

中文别名：异可利定;甲状球蛋白; 甲状腺球蛋白(来源于牛); THYROGLOBULIN 来源于牛甲状腺;

性状：Lyophilized

理论分子量：660

功能：Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

亚基：Homodimer.

亚细胞定位：Secreted.

组织特异性：Thyroid gland specific.

翻译后修饰：Sulfated tyrosines are desulfated during iodination.

疾病：Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.

           Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.

相似性：Belongs to the type-B carboxylesterase/lipase family.

               Contains 11 thyroglobulin type-1 domains.

SWISS：P01266

Gene ID：7038

活性：Not tested

序列：Purified native protein

纯度：>95% as determined by SDS-PAGE

内毒素

Not analyzed

保存条件：Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

数据库链接：Entrez Gene: 7038 Human 

                      Entrez Gene: 21819 Mouse

                      Entrez Gene: 24826 Rat

                      SwissProt: P01266 Human

                      SwissProt: O08710 Mouse

                      SwissProt: P06882 Rat

背景资料：Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.