实际分子量 70kDa 靶标 UBQLN4 别名 UBQLN4;A1U;A1Up;C1orf6;CIP75;UBIN 宿主 Rabbit 稀释比例 WB 1:2000-5000. IHC 1:50-200. Gene ID 56893 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot Q9NRR5 蛋白分子量 25/64kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 Recombinant protein of human UBQLN4 亚型 IgG 纯化方法 Affinity purification 背景资料 Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). Public Immunogen Range 1-63aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 WB;IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。