靶标 CHMP5 别名 apoptosis-related protein PNAS-2 ;C9orf83 ;CGI 34 ;Charged multivesicular body protein 5 ;CHMP 5 ;CHMP family, member 5 ;chmp5 ;CHMP5_HUMAN ;Chromatin modifying protein 5 ;Chromatin-modifying protein 5 ;Chromosome 9 open reading frame 83 ;HGNC:26942 ;HSPC177 ;hVps60 ;PNAS 2 ;SNF7 domain containing protein 2 ;SNF7 domain-containing protein 2 ;SNF7DC2 ;Vacuolar protein sorting 60 ;Vacuolar protein sorting-associated protein 60 ;Vps60 宿主 Rabbit 预测交叉反应 Zebrafish;Orangutan 稀释比例 IHC 1:50-200. Gene ID 51510 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot Q9NZZ3 蛋白分子量 20/25kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human CHMP5 亚型 IgG 纯化方法 Affinity purification 背景资料 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. Public Immunogen Range 1-220aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 IHC 规格 50ul 100ul