靶标 SHC1 别名 FLJ26504; p66; p66SHC; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC 1; SHC A; SHC adaptor protein 1; Shc; SHC transforming protein 1; SHC transforming protein; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; SHC1; SHC1_HUMAN; SHCA; Src homology 2 domain-containing-transforming protein C1 宿主 Rabbit 预测交叉反应 Bovine;Orangutan 稀释比例 IHC 1:50-200. Gene ID 6464 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot P29353 蛋白分子量 40/47/52/63kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human SHC1 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Public Immunogen Range 125-474aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 IHC 规格 50ul 100ul