实际分子量 154kDa 靶标 COL18A1 别名 Antiangiogenic agent; COIA1_HUMAN; Col18a1; Collagen alpha 1(XVIII) chain; Collagen type XVIII alpha 1; Endostatin; KNO; KNO1; KS; Multi functional protein MFP 宿主 Rabbit 稀释比例 WB 1:2000-5000. IHC 1:50-200. Gene ID 80781 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot P39060 蛋白分子量 136/154/178kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 A synthetic peptide of Human COL18A1 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. Public Immunogen Range 1465-1515/1754aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB IHC 规格 50ul 100ul