靶标 DCC 别名 Colorectal cancer related chromosome sequence 18; Colorectal cancer suppressor; CRC 18; CRC18; CRCR 1; CRCR1; DCC; DCC_HUMAN; Deleted in colorectal cancer protein; Deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; Netrin receptor DCC; Tumor suppressor protein DCC 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 1630 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot P43146 蛋白分子量 158kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 A synthetic peptide of Human DCC 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. Public Immunogen Range 1025-1075/1447aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 IHC 规格 50ul 100ul